Dmitrii V. Tchekhovskoi

Publications

The NISTmAb Tryptic Peptide Spectral Library for Monoclonal Antibody Characterization

February 09, 2018

Author(s):

Qian Dong, Yuxue Liang, Xinjian Yan, Sanford P. Markey, Yuri A. Mirokhin, Dmitrii V. Tchekhovskoi, Tallat H. Bukhari, Stephen E. Stein

We describe the creation of a mass spectral library composed of all identifiable spectra derived from the tryptic digest of a therapeutic monoclonal antibody...

Decoy Methods for False Discovery Rate Estimation in High Mass Accuracy Peptide Spectral Library Searches

February 02, 2018

Author(s):

Zheng Zhang, Meghan C. Burke, Yuri A. Mirokhin, Dmitrii V. Tchekhovskoi, Sanford P. Markey, Wen Yu, Raghothama Chaerkady, Sonja Hess, Stephen E. Stein

Spectral library searching (SLS) is an attractive alternative to sequence database searching (SDS) for peptide identification due to its speed, sensitivity,...

Combining fragment ion and neutral loss matching during mass spectral library searching: A new general-purpose algorithm applicable to illicit drug identification

November 20, 2017

Author(s):

Arun S. Moorthy, William E. Wallace, Anthony J. Kearsley, Dmitrii V. Tchekhovskoi, Stephen E. Stein

A mass spectral library search algorithm that identifies compounds that differ from library compounds by a single inert structural component is...

The Hybrid Search: A Mass Spectral Library Search Method for Discovery of Modifications in Proteomics

April 03, 2017

Author(s):

Meghan C. Burke, Yuri A. Mirokhin, Dmitrii V. Tchekhovskoi, Sanford P. Markey, Stephen E. Stein, Jenny Heidbrink Thompson, Christopher Larkin

We present a mass spectral library based method to identify tandem mass spectra of peptides that contain unanticipated modifications and amino acid variants...

Mass Spectral Library Quality Assurance by Inter-Library Comparison

April 02, 2017

Author(s):

William E. Wallace, Weihua Ji, Dmitrii V. Tchekhovskoi, Karen W. Phinney, Stephen E. Stein

A method to discover and correct errors in mass spectral libraries is described. Comparing across a set of highly curated reference libraries compounds that...