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Concepcion (Connie) Remoroza (Assoc)

Research Chemist

Dr. Remoroza's research interest is on carbohydrates and enzyme chemistry, biochemistry, enzymatic fingerprinting and modification of hydrocolloids and stabilizers, biorefinery, prebiotics/probiotics, glycan, glycopeptides and glycolipids from biological serum, plant cell wall materials, bioanalytical chemistry, molecular structural analysis by liquid chromatography and mass spectrometry, downstream processing (protein purification). Her current project is the creation and annotation of mass spectral library of oligosaccharides, glycan, glycopeptides, glycolipids from biological serum and viral proteins.

Projects

  • Mass Spectral Library of Human Milk Oligosaccharides  (HMOs)

        Online: https://chemdata.nist.gov/srmd-1953-glycan/spectra

        For download:  https://chemdata.nist.gov/dokuwiki/doku.php?id=peptidew:oligo

  • Mass Spectral Library of Mammalian Milk Oligosaccharides 

        For download:  https://chemdata.nist.gov/dokuwiki/doku.php?id=peptidew:lib:nonhumanmilk

  • Mass Spectral library of glycopeptides for SARS CoV2 spike proteins and human plasma
    • We are currently developing mass spectral libraries of  glycopeptides for SARS-CoV2 proteins. NIST is now employing its expertise to assist biomedical researchers in characterizing SARS-CoV 2 proteins, especially the so-called ‘spike’ protein, which is responsible for entry of the virus into host cells and a principal target for developing treatments and vaccines. Knowledge of these structural differences provides important clues for how the virus infects cells and replicates, and also informs development of treatments and vaccines. 
    • Along with this project is the creation of a comprehensive mass spectral libraries of glycopeptides for various glycoproteins in human plasma.

 

Representative scientific publications

        https://scholar.google.com/citations?user=3jI4jgwAAAAJ&hl=en

Scientific Society Membership

  • Member, American Society for Mass Spectrometry, 2016-present          
  • Full Member, Philippine American Academy of Scientists and Engineers 2016-present
  • Board member, Washington Chromatography Discussion Group, 2018

 

 

    Awards

    • Distinguished Associate, MML Accolades Technical Excellence 2020
    • Most Outstanding Poster Presentation in Biology, Biotechnology & Chemistry, NIST Sigma Xi Research Honor Society 2017, Maryland, US
    • Distinguished Returning Scientist (Balik Scientist) 2015, Philippine Council Energy Emerging Research & Devt., Department of Science and Technology, Philippines  
    • Best in Poster Presentation 2011, 16th Gums and Stabilisers for the Food Industry Conference, Netherlands
    • European Communities PolymodE Ph.D. Project 2009, Grant agreement no. 222628  Wageningen University, The Netherlands
    • Master Scholarship Program of the Netherlands Fellowship Association 2006, Wageningen University, The Netherlands

    Publications

    Increasing the Coverage of a Mass Spectral Library of Milk Oligosaccharides Using a Hybrid- Search-Based Bootstrapping Method and Milks from a Wide Variety of Mammals

    Author(s)
    Concepcion A. Remoroza, Tytus D. Mak, Yuri A. Mirokhin, Sergey L. Sheetlin, Xiaoyu Yang, Stephen E. Stein, Power L. Michael, San Andres V. Joice, Yuxue Liang
    This study significantly expands both the scope and method of identification for construction of a previously reported tandem mass spectral library of 74 human
    Created July 30, 2019, Updated June 15, 2021