Skip to main content
U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Arlin B Stoltzfus (Fed)

Arlin Stoltzfus received his Ph.D. in Biology from the University of Iowa  in molecular population genetics. He then converted to computational biology during a post-doctoral fellowship with W. Ford Doolittle.  He joined NIST in 1999 as a Research Biologist working at the NIST-UMD joint research center IBBR (formerly CARB).  In 2016 he became a data scientist with the MML Office of Data and Informatics.  He divides his time between ODI service and computer-based research.  
Sample Publications

Yu, G., and A. Stoltzfus. 2012. “Population diversity of ORFan genes in Escherichia coli.”. Genome Biol Evol 4(11):1176-87.

Rutger A. Vos, James P. Balhoff, Jason A. Caravas, Mark T. Holder, Hilmar Lapp, Wayne P. Maddison, Peter E. Midford, Anurag Priyam, Jeet Sukumaran, Xuhua Xia, Arlin Stoltzfus; NeXML: Rich, Extensible, and Verifiable Representation of Comparative Data and Metadata. Syst Biol 2012; 61 (4): 675-689.

Prosdocimi, F., B. Chisham, E. Pontelli, J. D. Thompson, and A. Stoltzfus. 2009. “Initial implementation of a comparative data analysis ontology.”. Evol Bioinform Online 5:47-66.

Stoltzfus, A., and L. Y. Yampolsky. 2009. “Climbing mount probable: mutation as a cause of nonrandomness in evolution.”. J Hered 100(5):637-47.

T. Hladish, V. Gopalan, C. L. Liang, W. G. Qiu, P. J. Yang, and A. Stoltzfus. 2007. Bio::NEXUS: a Perl API for the NEXUS format for comparative biological data. BMC Bioinformatics 8:191.

V. Gopalan, W.G. Qiu, M.Z. Chen and A. Stoltzfus. 2006. Nexplorer: Phylogenetic browsing and manipulation of sequence family data. Bioinformatics 22(1):120-1.

L.Y. Yampolsky and A. Stoltzfus. 2005. The Exchangeability of Amino Acids in Proteins. Genetics 170, 1459-1472.

L. Y. Yampolsky and A. Stoltzfus. 2001. Bias in the introduction of variation as an orienting factor in evolution, Evol Dev, 3, 73-83.

A. Stoltzfus. 1999. On the possibility of constructive neutral evolution. J. Mol. Evol. 49(2):169-181.

A. Stoltzfus, D.F. Spencer, M. Zuker, J.M. Logsdon, Jr.,and W.F. Doolittle. 1994. Testing the exon theory of genes: the evidence from protein structure. Science 265:202-7.

NIST-NRC Postdoctoral Fellowship:

2-year fellowship in computational studies of molecular evolution at NIST (US citizens only). $63,400 salary plus benefits, relocation expenses included. Application deadlines Feb. 1 and Aug. 1. Contact Arlin Stoltzfus if interested in writing proposal (3000 words).



Amino Acid Exchangeability from Experimental Data

L Y. Yampolsky, Arlin Stoltzfus
Amino acid sequence differences between proteins are often interpreted by reference to a pairwise measure of amino acid similarity, based either on observed

Mutation-Biased Adaptation in a Protein NK Model

Arlin B. Stoltzfus
Evolutionary trends responsible for systematic differences in genome and proteome composition have been attributed to GC:AT mutation bias in the context of
Created May 21, 2019, Updated December 8, 2022