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Search Publications by Arlin B Stoltzfus

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Displaying 1 - 10 of 10

The mutation spectrum shapes the spectrum of adaptive substitutions

May 20, 2021
Alejandro Cano, Hana Rozhonova, Arlin Stoltzfus, David McCandlish, Joshua Payne
Evolutionary adaptation can be conceived as a series of substitutions representing mutation-fixation events. The changes that are more likely will appear more frequently in the aggregate spectrum of adaptive substitutions. Recent studies establish that

Climbing Mount Probable: Mutation as a Cause of Nonrandomness in Evolution

October 1, 2009
Arlin B. Stoltzfus
Genomes differ systematically in Guanine-plus-Cytosine (GC) content. GC-rich genomes encode proteins enriched in amino acids with GC-rich codons, such as Glycine (with codons GGT, GGC, GGA, GGG), while AT-rich genomes are enriched in amino acids with AT

Mutation-Biased Adaptation in a Protein NK Model

October 1, 2006
Arlin B. Stoltzfus
Evolutionary trends responsible for systematic differences in genome and proteome composition have been attributed to GC:AT mutation bias in the context of neutral evolution or to selection acting on genome composition. A possibility that has been ignored

Mutationism and the dual causation of evolutionary change

May 1, 2006
Arlin B. Stoltzfus
The rediscovery of Mendel's laws a century ago launched the science that William Bateson called "genetics," and led to a new view of evolution combining selection, particulate inheritance, and the newly characterized phenomenon of "mutation." This

Intron and Exons

October 17, 2001
Arlin B. Stoltzfus
An intron (or intervening sequence) is a segment of RNA excised from a gene transcript, with concomitant ligation of flanking segments called exons. Introns of some type are found in every kingdom of cellular life, and also in viruses, bacteriophages and

Bias in the Introduction of Variation as an Orienting Factor in Evolution

January 1, 2001
L Y. Yampolsky, Arlin B. Stoltzfus
According to New Synthesis doctrine, the direction of evolution is determined by selection and not by internal causes that act by way of propensities of variation. This doctrine rests on the theoretical claim that because mutation rates are small in

Amino Acid Exchangeability from Experimental Data

L Y. Yampolsky, Arlin B. Stoltzfus
Amino acid sequence differences between proteins are often interpreted by reference to a pairwise measure of amino acid similarity, based either on observed evolutionary transition probabilities, or on some physicochemical model of effects. However