The SF-424 Research and Related (R&R) Application Guidance provides instructions to organizations interested in preparing an application in response to a Notice of Funding Opportunity (NOFO), formerly known as the Federal Funding Opportunity (FFO), using the Application for Federal Assistance SF-424 R&R application package. Use of the SF-424 R&R will be specified in the particular NOFO. Any information or requirements contained in a specific NOFO or program policy supersede the guidance provided in this document. This guide is not intended to be used as guidance for NOFOs requiring the use of the SF-424 Non-Construction application.