Parr, R.
, Dhir, R.
, Jakupciak, J.
, Reguly, B.
, Montelpare, W.
and Dakubo, G.
(2021),
3.4 kb Mitochondrial Genome Deletion Serves as a Surrogate Predictive Biomarker for Prostate Cancer in Histopathologically Benign Biopsy Cores, Journal of Molecular Diagnostics
(Accessed October 27, 2025)
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3.4 kb Mitochondrial Genome Deletion Serves as a Surrogate Predictive Biomarker for Prostate Cancer in Histopathologically Benign Biopsy Cores
Published
Author(s)
Ryan L. Parr, Rajiv Dhir, , Brian Reguly, William Montelpare, Gabriel D. Dakubo
Abstract
Recently, we described a 3.4kb mitochondrial genome deletion having significance for identifying both malignant and benign prostate tissues (p<0.0001). Moreover, this biomarker was present in normal appearing tissue in close proximity to tumor, indicating a field cancerization effect. Here we report 4 case studies (3 malignant, 1 benign) suggesting that this field effect may occur in advance of tumorigenesis, or alternatively, identify the presence of a small tumor focus/foci which are difficult to detect with single, or even multiple sextant biopsy procedures.Citation
Journal of Molecular Diagnostics
Pub Type
Journals
Keywords
cancer, case histories, mitochondria, prediction
Citation
Issues
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Created October 12, 2021