Morphological and Phase Characterizations of Retrieved Calcium Phosphate Cement Implants

Published

February 1, 2001

Author(s)

Shozo Takagi, Laurence C. Chow, Milenko Markovic, C D. Friedman, P D. Costantino

Abstract

A self-hardening calcium phosphate cement (CPC), consisting of equimolar amounts of tetracalcium phosphate and dicalcium phosphate anhydrous, hardens when mixed with water and forms a resorbable hydroxyapatite (HA) as the end- product. The objective of this study was to investigate the changes of the phase and morphology of the CPC during hardening and aging under in vivo conditions. CPC samples retrieved 12 h after hardening in vivo had already contained carbonated HA (type B) even though the initial cement mixture did not contain carbonate as one of the solid components. The mass fraction of carbonate in the 12-h sample was about 1%. The results suggested that under in vivo conditions carbonate is readily available and this allows formation of carbonated HA in favor of carbonate-free HA. The carbonate content of the CPC samples retrieved 3 months after implantation was similar to that of the 12-h samples, and exterior surfaces of the 3-month samples appeared less crystalline than that of the 12-h samples.

Citation

Journal of Biomedical Materials Research

Volume

58

Issue

No. 1

Pub Type

Journals

Keywords

calcium phosphate biomaterial, calcium phosphate cement implant, carbonated hydroxyapatite, CPC characterization, dicalcium phosphate anhydrous, hydroxyapatite, self-hardening calcium phosphate cement, tetracalcium phosphate

Citation

Takagi, S. , Chow, L. , Markovic, M. , Friedman, C. and Costantino, P. (2001), Morphological and Phase Characterizations of Retrieved Calcium Phosphate Cement Implants, Journal of Biomedical Materials Research (Accessed October 16, 2025)