Recent Advances in Quantitative Synthetic-Polymer Mass Spectrometry at NIST

Published

January 1, 2004

Author(s)

William E. Wallace, Charles M. Guttman

Abstract

Commensurate with NIST s mission to advance the state of quantitative measurement science we have worked to develop a method to determine absolute molecular mass distribution of synthetic polymers by mass spectrometry. Work has centered on using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) on low-mass, narrow-polydispersity polystyrene. We are developing a Taylor s expansion approach that may be used to guide the experimentalist in finding the correct measurement conditions to assure quantitation. Along with this we are developing an uncertainty budget (for both Type A and Type B uncertainties) so the experimenter can ascertain the level of confidence in the final quantitative measure of molecular mass distribution.

Proceedings Title

ASMS Conference on Mass Spectrometry and Allied Topics | 52nd | Proceedings of the 52nd ASMS Conference on Mass Spectrometry and Allied Topics | American Society for Mass Spectrometry (ASMS)

Volume

33(1)

Conference Dates

May 23-27, 2004

Conference Location

Nashville, TN

Conference Title

ASMS Conference on Mass Spectrometry

Pub Type

Conferences

Download Paper

Local Download

Keywords

mass spectrometry, molecular mass distribution, polymer quantitation

Citation

Wallace, W. and Guttman, C. (2004), Recent Advances in Quantitative Synthetic-Polymer Mass Spectrometry at NIST, ASMS Conference on Mass Spectrometry and Allied Topics | 52nd | Proceedings of the 52nd ASMS Conference on Mass Spectrometry and Allied Topics | American Society for Mass Spectrometry (ASMS), Nashville, TN, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=852391 (Accessed October 13, 2025)