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PUBLICATIONS

Towards optimization and characterization of dye-embedded gold nanoclusters for multiplexed optical imaging

Published

Author(s)

Michael A. McDonald, Angela R. Hight Walker

Abstract

Metallic nanoparticle aggregates coupling strong surface plasmons with a Raman reporter molecule have been developed for application in multiplexed optical imaging. Of interest to our work is the ability of the agents to serve as surface-enhanced Raman spectroscopy (SERS) probes. We present the seed-mediated synthesis and characterization of rhodamine B isothiocyante Au nanoclusters (RhB-AuNCs). RhB-AuNCs are anisotropic structures which contain the Raman reporter, RhB, embedded between a gold aggregate core and gold surface layer. In contrast to typical SERS studies, the Raman signal originates from the probe (RhB-AuNCs) and not from RhB incubated with a noble metal colloid. Characterization of the probes optical properties is presented. The overall goal of our study is to prepare probes that may be used for the identification and spectroscopic labeling of multiple molecular biomarkers utilizing SERS imaging.
Proceedings Title
Plasmonics in Biology and Medicine VI
Proceedings of SPIE Volume 7192
Volume
7192
Conference Dates
January 24-29, 2009
Conference Location
San Jose, CA
Conference Title
Conference 7192 - BIOS 2009/Photonics West
Pub Type
Conferences

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Keywords

gold, nanoparticle, plasmonics, Raman, SERS
Nanochemistry

Citation

McDonald, M. and Hight, A. (2009), Towards optimization and characterization of dye-embedded gold nanoclusters for multiplexed optical imaging, Plasmonics in Biology and Medicine VI Proceedings of SPIE Volume 7192, San Jose, CA, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=901384 (Accessed October 10, 2025)

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Created February 26, 2009, Updated January 27, 2020
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