3D Polymer Scaffold Arrays

Published

December 5, 2010

Author(s)

Carl G. Simon Jr., Yanyin Yang, Shauna M. Dorsey, Murugan Ramalingam, Kaushik Chatterjee

Abstract

We have developed a combinatorial platform for screening the effect polymer scaffold properties and composition on cell response. Traditional research involves preparing samples one at a time for characterization and testing. Combinatorial and high-throughput (CHT) methods lower the cost of research by reducing the amount of time and material required for experiments by combining many samples into miniaturized specimens. In order to help accelerate biomaterials research, many new CHT methods have recently been developed for screening cell-material interactions. However, biomaterials are frequently used to fabricate 3D scaffolds, cells exist in vivo in a 3D environment and cells cultured in a 3D environment in vitro typically behave more physiologically than those cultured on a 2D surface. Thus, we have developed CHT methods for screening cell-material interactions where the materials are presented to cells in a 3D scaffold format.

Citation

Methods in Molecular Biology

Volume

671

Publisher Info

Humana Press Inc, Totowa, NJ

Pub Type

Books

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Keywords

array, biomaterials, cell adhesion, cell proliferation, combinatorial methods, polymer scaffold, rapid screening

Citation

Simon, C. , Yang, Y. , Dorsey, S. , Ramalingam, M. and Chatterjee, K. (2010), 3D Polymer Scaffold Arrays, Humana Press Inc, Totowa, NJ, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=854150 (Accessed October 16, 2025)