NOTICE: Due to a lapse in annual appropriations, most of this website is not being updated. Learn more.

Form submissions will still be accepted but will not receive responses at this time. Sections of this site for programs using non-appropriated funds (such as NVLAP) or those that are excepted from the shutdown (such as CHIPS and NVD) will continue to be updated.

U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

PUBLICATIONS

Effect of 3D Hydrogel Scaffold Stiffness on Human Bone Marrow Stromal Cell Differentiation

Published

Author(s)

Carl G. Simon Jr., Sapun Parekh, Marcus T. Cicerone, Sheng Lin-Gibson, Kaushik Chatterjee, Marian F. Young

Abstract

There is growing recognition cells can sense and respond to the mechanical properties of tissue scaffolds and that these interactions are critical in optimizing scaffold design [1-4]. Previous studies in planar 2D culture format have shown that human bone marrow stromal cell (hBMSC) differentiation and proliferation change in response to change in stiffness of the underlying substrate. Herein, the effect of matrix modulus on differentiation of hBMSC within three-dimensional (3D) polyethylene glycol tetramethacrylate (PEGTM) hydrogel scaffolds is examined.
Proceedings Title
RESBIO Cells on Polymeric Biomaterials
Conference Dates
October 26-29, 2010
Conference Location
Piscataway, NC
Pub Type
Conferences

Download Paper

Local Download

Keywords

tissue engineering, hydrogel scaffold, stem cell, cell differentiation, modulus
Bioscience, Biomaterials, Health, Materials and Polymers

Citation

Simon, C. , Parekh, S. , Cicerone, M. , Lin-Gibson, S. , Chatterjee, K. and Young, M. (2010), Effect of 3D Hydrogel Scaffold Stiffness on Human Bone Marrow Stromal Cell Differentiation, RESBIO Cells on Polymeric Biomaterials, Piscataway, NC, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=906309 (Accessed October 15, 2025)

Issues

If you have any questions about this publication or are having problems accessing it, please contact [email protected].

Created November 1, 2010, Updated February 19, 2017
Was this page helpful?