Quantifying the Surface Coverage of Conjugate Moleucles on Functionalized Nanoparticles

Published

November 22, 2007

Author(s)

Leonard F. Pease III, De-Hao D. Tsai, Rebecca A. Zangmeister, M Zachariah, Michael J. Tarlov

Abstract

Electrospray-differential mobility analysis (ES-DMA) represents an attractive tool to determine directly the coverage and conformation of long, flexible molecules on engineered nanoparticles. For example, nanoparticles coated with single-stranded DNA (ssDNA) hold potential for a variety of uses ranging from cancer treatments to DNA sequencing probes. However, rapid quantification of the coverage and configuration of the ssDNA coating remains challenging but of clear importance for these properties affect the stability, properties and utility of the nanoparticle suspension. We demonstrate ES-DMA as a new nano-metrology tool for the characterization of these biologically interesting, engineered nanoparticles, and we report a simple random walk model to determine the coverage of the DNA.

Citation

Journal of Physical Chemistry C

Volume

111

Issue

46

Pub Type

Journals

Keywords

bioaerosol, differential mobility analysis, electrospray, nanometrology, nanoparticles, random walk, single-stranded DNA

Citation

Pease III, L. , Tsai, D. , Zangmeister, R. , Zachariah, M. and Tarlov, M. (2007), Quantifying the Surface Coverage of Conjugate Moleucles on Functionalized Nanoparticles, Journal of Physical Chemistry C (Accessed October 13, 2025)