NOTICE: Due to a lapse in annual appropriations, most of this website is not being updated. Learn more.

Form submissions will still be accepted but will not receive responses at this time. Sections of this site for programs using non-appropriated funds (such as NVLAP) or those that are excepted from the shutdown (such as CHIPS and NVD) will continue to be updated.

U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

PUBLICATIONS

Tools and Approaches for the Assessment of Nanomaterial Induced Oxidative DNA Damage

Published

Author(s)

Elijah J. Petersen, Bryce J. Marquis, Pawel Jaruga, M Miral Dizdar, Bryant C. Nelson

Abstract

Hyphenated mass spectrometry techniques have been employed as one of the primary analytical tools for investigating the effects of ionizing radiation, chemical/biological carcinogens, and oxygen derived free radicals on the induction and subsequent repair of oxidatively-induced DNA damage (DNA lesions) in living systems. The National Institute of Standards and Technology has established a comprehensive research program focused on identifying mechanisms of DNA damage caused by commercially relevant engineered nanoparticles (NPs) using these techniques for the quantification of oxidatively-induced DNA damage. We present an overview of our recent findings from studies on metal (gold) and metal oxide (ultrafine superparamagnetic iron oxide) nanoparticles using isotope dilution liquid chromatography and gas chromatography/mass spectrometry analysis, respectively.
Proceedings Title
Nanotech 2012
Conference Dates
June 18-21, 2012
Conference Location
Santa Clara, CA
Pub Type
Conferences

Download Paper

Local Download

Keywords

nanotoxicology, Comet assay, genotoxicity, biomarker, toxicology
Environmental health

Citation

Petersen, E. , Marquis, B. , Jaruga, P. , , M. and Nelson, B. (2012), Tools and Approaches for the Assessment of Nanomaterial Induced Oxidative DNA Damage, Nanotech 2012, Santa Clara, CA, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=911145 (Accessed October 7, 2025)

Issues

If you have any questions about this publication or are having problems accessing it, please contact [email protected].

Created June 20, 2012, Updated February 19, 2017
Was this page helpful?