Forbes, T.
and Kralj, J.
(2012),
Engineering and Analysis of Surface Interactions in a Microfluidic Herringbone Micromixer, Lab on A Chip, [online], https://doi.org/10.1039/c2lc40356k (Accessed May 8, 2026)
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Engineering and Analysis of Surface Interactions in a Microfluidic Herringbone Micromixer
Published
Author(s)
,
Abstract
We developed a computational model and theoretical framework to investigate the geometrical optimization of particle-surface interactions in a herringbone micromixer. The enhancement of biomolecule- and particle-surface interactions in microfluidic devices through mixing and streamline disruption holds promise for a variety of applications. This analysis provides guidelines for optimizing the frequency and specific location of surface interactions based on the flow pattern and relative hydraulic resistance between a groove and the effective channel. The channel bottom, i.e., channel surface between grooves, was identified as the dominant location for surface contact. In addition, geometries that decrease the groove-to-channel hydraulic resistance improve contact with the channel top. Thus, herringbone mixers appear useful for a variety of surface-interaction applications; yet, they have largely not been employed in an optimized fashion.Citation
Lab on A Chip
Volume
12
Issue
15
Pub Type
Journals
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Keywords
Microfluidics, Surface Interactions, Numerical Analysis, Herringbone Mixer
Citation
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Created May 18, 2012, Updated November 10, 2018