Bergeron, D.
, Cessna, J.
, Golas, D.
, Young, R.
and Zimmerman, B.
(2014),
Dose calibrator manufacturer-dependent bias in assays of 123I, Applied Radiation and Isotopes, [online], https://doi.org/10.1016/j.apradiso.2014.03.018
(Accessed October 8, 2025)
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Dose calibrator manufacturer-dependent bias in assays of 123I
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Abstract
Calibration factors for commercial ionization chambers (i.e. dose calibrators) were determined for a solution of 123I; the activity was based on the 1976 NBS standard. A link between the NIST standard and the International Reference System (SIR) was established. The two major U.S. dose calibrator manufacturers recommend oppositely biased calibration factors, giving a spread of 11.3 % in measured activities. With modern quantitative imaging techniques capable of ≤ 10 % accuracy, this bias for a SPECT nuclide is highly significant.Citation
Applied Radiation and Isotopes
Pub Type
Journals
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Keywords
Ionization chamber, dose calibrator, I-123, secondary standard, quantitative imaging
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Created March 25, 2014, Updated October 12, 2021