Agentic AI-Assisted Coding Offers a Unique Opportunity to Instill Epistemic Grounding during Software Development

Published

July 17, 2026

Author(s)

Magnus Palmblad, Jared Ragland, Benjamin Neely

Abstract

The capabilities of AI-assisted coding are progressing at a breakneck speed. Chat-based vibe coding has evolved into fully fledged AI-assisted, agentic software development using agent scaffolds, where the human developer creates a plan that agentic AIs implement. One current trend is utilizing documents beyond this plan such as project- and method-scoped documents. Here, we propose GROUNDING.md, a community-governed, field-scoped epistemic grounding document, using mass spectrometry-based proteomics as an example. This explicit field-scoped document encodes Hard Constraints (non-negotiable validity invariants empirically required for scientific correctness) and Convention Parameters (community-agreed defaults). In this framework, Hard Constraints are intended to function as field-scoped validity constraints that take precedence over lower-priority context when properly loaded, while Convention Parameters capture community-agreed defaults. In practice, GROUNDING.md will empower a non-domain expert to generate code, tools, and software that have best practices baked in at the ground level, providing confidence to the software developer but also to those reviewing or using the final product. It seems easier to have agentic AIs adhere to guidelines than humans, and this opportunity allows organizations to develop epistemic grounding documents in such a way that keeps domain experts in the loop in a future of democratized generation of bespoke software solutions.

Citation

ACS Journal of Proteome Research

Volume

25

Issue

8

Pub Type

Journals

Download Paper

https://doi.org/10.1021/acs.jproteome.6c00398

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Keywords

proteomics, AI-assisted, agentic software development environments

Citation

Palmblad, M. , Ragland, J. and Neely, B. (2026), Agentic AI-Assisted Coding Offers a Unique Opportunity to Instill Epistemic Grounding during Software Development, ACS Journal of Proteome Research, [online], https://doi.org/10.1021/acs.jproteome.6c00398, https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=961958 (Accessed August 13, 2026)

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