Larrea, A.
, Dai, C.
, Schwenk, J.
, Neely, B.
, Martin, C.
and Perez-Riverol, Y.
(2026),
Blood proteomics: insights from public data, Genome Biology, [online], https://doi.org/10.1186/s13059-026-04027-9, https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=960429
(Accessed March 13, 2026)
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Blood proteomics: insights from public data
Published
Author(s)
Asier Larrea, Chengxin Dai, Jochen Schwenk, , Cesar Martin, Yasset Perez-Riverol
Abstract
The circulating blood proteome comprises soluble and cellular components that reflect physiological and pathological states across tissues. Advances in mass spectrometry and affinity-based proteomics have improved sensitivity and throughput, enabling the generation of public blood proteomics resources. However, comprehensive assessments of these datasets remain limited. This work reviews the cellular and molecular complexity of publicly available blood proteomics data, recent methodological developments, and the complementarity of diverse data sources across the abundance range, while outlining remaining challenges for translating blood proteomics into personalized medicine.Citation
Genome Biology
Volume
27
Pub Type
Journals
Download Paper
Keywords
proteomics, blood, mass spectrometry, affinity-based proteomics, aptamer-based proteomics
Citation
Issues
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Created March 12, 2026