Abstract
As DNA typing technologies have advanced and sensitivity improved, measurement and interpretation issues related to low template, degraded, and complex DNA mixtures encountered in forensic laboratories have evolved. In turn, the forensic DNA typing community has requested more relevant reference materials to support the validation of their methods. The stochastic nature of these measurements, in tandem with the goal of reproducibly providing "casework-like" sample types, poses a challenge in meeting the robust characterization and the long-term stability required for a Standard Reference Material classification. NIST has introduced a new category of exploratory material called a Research Grade Test Material (RGTM) to collaboratively evaluate fit-for-purpose needs within a community. Laboratories can request the material with an agreement that data collected from the samples will be shared with NIST. A data portal hosted through STRBase (
https://strbase.nist.gov/Information/RGTM_10235) was created to receive and publicly share results. The goal is that these samples and companion data portal resources will support validation efforts, facilitate data sharing, and guide further development of forensically relevant reference materials.