Kwon, I.
, Lee, J.
, Tokumasu, F.
, Lee, S.
and Hwang, J.
(2025),
PERSPECTIVE Hyperspectral analysis to assess gametocytogenesis stage progression in malaria-infected human erythrocytes, Journal of Biomedical Optics, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=958535
(Accessed October 7, 2025)
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
PERSPECTIVE Hyperspectral analysis to assess gametocytogenesis stage progression in malaria-infected human erythrocytes
Published
Author(s)
Ik Hwan Kwon, Ji Youn Lee, Fuyuki Tokumasu, Sang Won Lee,
Abstract
Developments of anti-gametocyte drugs have been delayed due to insufficient understanding of gametocyte biology. We report a systematic workflow of data processing algorithms to quantify changes in the absorption spectrum and cell morphology of single malaria-infected erythrocytes. These changes may serve as biomarkers instrumental for the future development of antimalarial strategies, especially for anti-gametocyte drug design and testing. Image-based biomarkers may also be useful for nondestructive, label-free malaria detection and drug efficacy evaluation in resource-limited communities.Citation
Journal of Biomedical Optics
Volume
30
Issue
2
Pub Type
Journals
Download Paper
Keywords
malaria, plasmodium falciparum, erythrocyte, gametocytes, gametocytogenesis, hyperspectral imaging, spectral angle mapper, hemoglobin, hemozoin, supervised classification
Citation
Issues
If you have any questions about this publication or are having problems accessing it, please contact [email protected].
Created January 14, 2025, Updated February 27, 2025