Applying the Cytocentric Principles to Regenerative Medicine for Reproducibility

Published

October 18, 2022

Author(s)

Carl Simon Jr.

Abstract

We establish here a set of cytocentric principles to improve use of cells for regenerative medicine (RM) applications. The five cytocentric principles are cells need 1) full-time protection from contamination, 2) physiologic simulation, 3) proper conditions full-time (not part-time), 4) individualized conditions and 5) dynamic conditions as populations change. Just like quality principles have improved product quality in almost every other industry, from automobiles to computer chips, the cytocentric principles have been designed to improve cell and tissue product quality. Meeting the biological needs of yeast produces the best, most reproducible batch of bread or beer. Meeting the needs of human cells will produce the best, most reproducible products for RM. We believe that control of the optimal environmental parameters will be a cornerstone of every manufacturing process for RM products and pave the way for these technologies to become the next standard of care.

Citation

Stem Cells Translational Medicine

Pub Type

Journals

Download Paper

https://doi.org/10.1007/s40778-022-00219-8

Local Download

Keywords

regenerative medicine, cell culture, environmental control

Citation

Simon Jr., C. (2022), Applying the Cytocentric Principles to Regenerative Medicine for Reproducibility, Stem Cells Translational Medicine, [online], https://doi.org/10.1007/s40778-022-00219-8, https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=933435 (Accessed October 9, 2025)