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PUBLICATIONS

Rapid Detection of Bacterial Response to Antibiotics through Induced Phase Noise of a Resonant Crystal

Published

Author(s)

Fred Walls, Danielle France, Ward L. Johnson, John Miles, Nikki Rentz, William Cordell, Shelley Kon, Ian Babson

Abstract

A new low cost, multi-channel desktop digital instrument was developed which measures bacteria response when exposed to multiple antibiotics vs a control channel with no antibiotic in about an hour by detecting PM noise induced by their mechanical motion when tightly tethered to a resonator. The motivation for this work comes from the approximately 13 million urinary tract infections (UTIs) leading to some 63,000 deaths yearly in the USA and many more worldwide, primarily due to E. Coli and the two-day delay in diagnosing antibiotic resistance. Rapid determination of efficacy could potentially save lives and extend antibiotic lifetimes.
Conference Dates
July 7-17, 2021
Conference Location
Paris (Virtual), FR
Conference Title
2021 Joint Conference of European Frequency and Time Forum & The IEEE International Frequency Control Symposium
Pub Type
Conferences

Download Paper

https://doi.org/10.1109/EFTF/IFCS52194.2021.9604273
Local Download

Keywords

Urinary tract infections, antibiotic resistance, E. Coli., crystal resonator, phase noise, antimicrobial susceptibility testing
Microbial measurements, Metrology and Cell measurements

Citation

Walls, F. , France, D. , Johnson, W. , Miles, J. , Rentz, N. , Cordell, W. , Kon, S. and Babson, I. (2021), Rapid Detection of Bacterial Response to Antibiotics through Induced Phase Noise of a Resonant Crystal, 2021 Joint Conference of European Frequency and Time Forum & The IEEE International Frequency Control Symposium, Paris (Virtual), FR, [online], https://doi.org/10.1109/EFTF/IFCS52194.2021.9604273, https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=933017 (Accessed October 9, 2025)

Issues

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Created November 18, 2021, Updated November 29, 2022
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