Deciphering Piezoelectric and Surface Charge Effects in Hydroxyapatite Osteoconduction via Piezoresponse Force Microscopy

Published

November 30, 2002

Author(s)

Youngjoon Han, Jeongjae Ryu, Andreas Schiffer, Jason Killgore, Seungbum Hong

Abstract

Electrical properties of hydroxyapatite (HAp), the main constituent of the mineralized portion of the cortical bone, and a key variable in Wolff's law, remain an enigma up to this date. In order to make a comparison between the contribution of the intrinsic surface zeta potential and the piezoelectric polarization charge in the osteoconduction at the surface of the sintered HAp, we used piezoresponse force microscopy (PFM) to measure the surface charge density and the effective piezoelectric coefficient at the surface of a processed HAp pellet. Using theoretical models to construe the electrostatic interaction involved in a PFM setup and performing assorted PFM analysis coupled with Pearson correlation of the scan data, we characterized the physical and chemical origin of the electromechanical schemes observed at the HAp surface, as well as their controllability. This work also provides an approach to investigate surface electrical properties that are applicable in many other biomaterial systems.

Citation

Nature Nanotechnology

Pub Type

Journals

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Citation

Han, Y. , Ryu, J. , Schiffer, A. , Killgore, J. and Hong, S. (2002), Deciphering Piezoelectric and Surface Charge Effects in Hydroxyapatite Osteoconduction via Piezoresponse Force Microscopy, Nature Nanotechnology, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=930068 (Accessed October 8, 2025)