Quantification Of Genomic DNA Damage In Lung and Nasal Epithelium and Response To Allergen Challenge

Published

February 1, 2018

Author(s)

M Miral Dizdar, Koa Hosoki, Pawel Jaruga, Toshiko Itazawa, Erdem Coskun, Sanjiv Sur

Abstract

Repair of oxidatively-induced DNA base lesions can stimulate innate and allergic airway inflammation. Specific allergenic extracts like ragweed pollen extract and cat dander extract (CDE) induce TLR4- dependent oxidative stress and DNA damage. These studies suggest that stimulation of an innate receptor/adaptor by allergenic extracts initiates excision of a set of DNA-base lesions. The extent of DNA damage in the genome of nasal epithelial cells of human subjects has not been reported.

Citation

Journal of Allergy and Clinical Immunology

Volume

141

Issue

2

Pub Type

Journals

Download Paper

DOI Link

Keywords

Allergic inflammation, Asthma, Cat dander, MyD88, Pollen

Citation

, M. , Hosoki, K. , Jaruga, P. , Itazawa, T. , Coskun, E. and Sur, S. (2018), Quantification Of Genomic DNA Damage In Lung and Nasal Epithelium and Response To Allergen Challenge, Journal of Allergy and Clinical Immunology, [online], https://doi.org/10.1016/j.jaci.2017.12.245 (Accessed November 6, 2025)