Joseph Curtis

Publications

Solution Conformation Differences between Conventional and CENP-A Nucleosomes are Accentuated by Reversible Deformation under High Pressure

June 12, 2025

Author(s)

Kushol Gupta, Nikolina Sekulic, Praveen Allu, Nicholas Sapp, Qingqiu Huang, Kathryn Sarachan, Mikkel Christensen, Reidar Lund, Susan N. Krueger, Joseph E. Curtis, Richard Gillilan, Gregory Van Duyne, Ben Black

Solution-based interrogation of the physical nature of nucleosomes has its roots in X-ray and neutron scattering experiments, including those that provided the

SEC-SAXS/MC Ensemble Structural Studies of the Microtubule Binding Protein Cdt1 Show Monomeric, Folded-Over Conformations

June 1, 2025

Author(s)

Kyle Smith, Srinivas Chakravarthy, Manas Chakraborty, Kristen M. Vosberg, Marco Tonelli, Maximilian G. Plach, Arabela A. Grigorescu, Joseph E. Curtis, Dileep Varma

Cdt1 is a mixed folded protein critical for DNA replication licensing and it also has a "moonlighting" role at the kinetochore via direct binding to

SAXS-A-FOLD: A Website for Fast Ensemble Modeling Optimizing the Fit of AlphaFold or User-Supplied Protein Structures with Flexible Regions to SAXS Data

May 29, 2025

Author(s)

Emre Brookes, Joseph E. Curtis, Aaron Householder, Mattia Rocco

AI programs such as AlphaFold (AF) are having a major impact on structural biology. However, predicted unstructured regions, the arrangement of linker-connected

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Joseph Curtis (Fed)

Publications