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A series of three photos show two liposomes fusing into one.
The National Institute of Standards and Technology will host a virtual-only workshop to discuss current state-of-the-art for basic liposome metrology and discuss liposome reference material development.
This workshop will host participants to discuss recent advances in the measurement of liposome physical-chemical properties including stability as well as ongoing efforts to develop a liposome-based reference material. The workshop will take place on September 21 and 22, 2022 from 10 AM EDT to 1 PM EDT. The workshop will feature presentations by speakers from government, industry, and academia, as well as open discussion breakout sessions focused on several topic areas.
Topics to be covered at this workshop include:
- Liposome physical-chemical metrology
- Optimal liposome reference material properties
- Instrumental characterization options and challenges
- Liposome reference material use cases and possible applications
This workshop will not discuss, nor will it address biological attributes such as potency, drug loading efficiency, in vitro or in vivo toxicity, etc.
NIST invites all interested stakeholders to register for this upcoming workshop to participate and share their views on liposome metrology and reference material development.
The deadline for registration is 5 PM EDT on September 14, 2022.
Day 1 (September 21, 2022)
|
Time |
Event/Speaker |
|
10:00 AM-10:05 AM |
Welcome and Introduction Presenter: Dr. Sean Lehman (NIST) |
|
10:05 AM-10:25 AM |
“A Long-term Study of the Size and Number Concentration of Liposomes in Fluid Aqueous Environments” Presenter: Dr. Kurt Benkstein (NIST) |
|
10:25 AM- 10:45 AM |
“Physicochemical Characterization of Liposomal Drug Products: Characterization Considerations and Challenges” Presenter: Dr. Jeff Clogston (Frederick National Laboratory for Cancer Research) |
|
10:45 AM- 11:05 AM |
“Certified Reference Materials for Lipid-Based Nanocarriers-Development and Unique Challenges” Presenter: Dr. Shan Zou (NRC-Canada) |
|
11:05 AM- 11:15 AM |
Brief Break |
|
11:15 AM- 11:35 AM |
“Measuring the Physical Properties of Liposomes with Multi-Detector-Asymmetric Flow Field Flow Fractionation” Presenter: Dr. Jérémie Parot (Sintef) |
|
11:35 AM- 12:25 PM |
Breakout Sessions, Day 1 Topic A: Liposome Physicochemical Properties Topic B: Physicochemical Characterization Methods Topic C: Reference Material Use Cases/Purposes |
|
12:25 PM 1:00 PM |
First Day Wrap-Up |
Day 2 (September 22, 2022)
|
Time |
Event/Speaker |
|
10:00 AM-10:05 AM |
Welcome Back Presenter: Dr. Sean Lehman (NIST) |
|
10:05 AM-10:25 AM |
“Characterizing LNP Size Distributions and Morphology with Combined CryoEM and Small-Angle Scattering Analysis” Presenter: Dr. Tom Cleveland (NIST) |
|
10:25 AM- 10:45 AM |
“Quality Control Strategies for mRNA-LNP Projects” Presenter: Dr. Eivor Örnskov (AstraZeneca) |
|
10:45 AM- 11:05 AM |
“Current Landscape of Physicochemical Methods for Characterizing Liposome Enabled Drug Products” Presenter: Dr. Bryant Nelson (NIST) |
|
11:05 AM- 11:15 AM |
Brief Break |
|
11:15 AM- 11:35 AM |
“Liposomal Nanoparticles Using Continuous Processing as Reference Materials” Presenter: Dr. Antonio Costa (Diant Pharma) |
|
11:35 AM- 12:30 PM |
Breakout Sessions, Day 2 Topic A: Reference Material Development Pathway Topic B: Documentary Standards for Liposomes |
|
12:30 PM 1:00 PM |
Workshop Wrap-Up |