limit-of-detection
1) For a test, the point at which the sensitivity of the test is such that the quantity or concentration of a component present is insufficient to produce a positive test result or be detected. 2) For instrumental analysis, the point below which it is not possible to reliably distinguish analytical signal data from instrument background noise; typically defined as three times the standard deviation of the average background noise; The LOD may be calculated to aid in setting an analytical threshold for the reporting and interpretation of alleles in a DNA profile electropherogram.
Committee
Wildlife Forensic Biology
Date Added to Lexicon
Standard Source (Designation Number Title of Standard. Publisher, Place, Year.)
ANSI/ASB 046 Wildlife Forensics Validation Standards—STR Analysis. AAFS Academy Standards Board (ASB), 410 North 21st Street, Colorado Springs, CO, 2019.
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