Serrell, D.
, Law, J.
, Slifka, A.
, Mahajan, R.
and Finch, D.
(2008),
A Uniaxial bioMEMS device for imaging single cell response during quantitative force-displacement measurements, Biomedical Microdevices, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=50612
(Accessed October 2, 2025)
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A Uniaxial bioMEMS device for imaging single cell response during quantitative force-displacement measurements
Published
Author(s)
, Jera Law, , Roop L. Mahajan, Dudley S. Finch
Abstract
Mechanical forces play a key role in many cellular processes such as apoptosis and differentiation. A microfabricated device has been developed for imaging of a single, adherent cell while quantifying force under an applied strain. The device works in a similar fashion to a displacement-controlled uniaxial tensile machine. The device was calibrated using a tipless AFM cantilever and shows excellent agreement with the calculated spring constant. A step input was applied to a single, adherent fibroblast cell and the viscoelastic response was characterized with a mechanical model. The adherent fibroblast was imaged using fluorescence and phase contrast techniques.Citation
Biomedical Microdevices
Volume
6
Pub Type
Journals
Download Paper
Keywords
bioMEMS, cell mechanics, fibroblast
Citation
Issues
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Created November 30, 2008, Updated October 12, 2021