Klein, K.
, Anderson, I.
and de, N.
(2011),
Tranmission Electron Microscopy with a Liquid Flow Cell, Journal of Microscopy, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=906875
(Accessed July 2, 2025)
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
Tranmission Electron Microscopy with a Liquid Flow Cell
Published
Author(s)
, , N. de Jonge
Abstract
The imaging of microscopic structures at nanometer-scale spatial resolution in a liquid environment is of interest for a wide range of studies. Transmission electron microscopy (TEM) provides a method for imaging with the requisite spatial resolution, but such imaging can be accomplished only with a means of isolating the liquid environment from the high vacuum of the instrument column, such as an impermeable cell with electron transparent windows. Recently, a liquid flow cell TEM holder equipped with a miniaturized viewing chamber has been developed and applied to the detection of high atomic number labeling nanoparticles by scanning TEM high-angle annular dark-field imaging. Here we demonstrate the application of the flow cell system for conventional TEM bright-field imaging of immobilized nanoparticles in a liquid of micrometer thickness.Citation
Journal of Microscopy
Volume
242
Pub Type
Journals
Download Paper
Keywords
in situ, liquid, nanoparticles, STEM, TEM
Citation
Issues
If you have any questions about this publication or are having problems accessing it, please contact [email protected].
Created January 20, 2011, Updated February 19, 2017