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Surfaces of Fluorinated Pyridinium Block-Copolymers with Enhanced Antibacterial Activity

Published

Author(s)

Sitaraman Krishnan, R J. Ward, A Hexemer, K E. Sohn, K L. Lee, E R. Angert, Daniel A. Fischer, E J. Kramer, Christopher K. Ober

Abstract

Polystyrene-block-poly(4-vinylpyridine) copolymers were quaternized with 1-bromohexane and 6-perfluorooctyl-1-bromohexane. Surfaces prepared from these polymers were characterized by contact angle measurements, near-edge X-ray absorption fine structure (NEXAFS) spectroscopy and X-ray photoelectron spectroscopy (XPS). The fluorinated pyridinium surfaces showed enhanced antibacterial activity compared to their non-fluorinated counterparts. Even a polymer with a relatively low molecular weight pyridinium block showed high antimicrobial activity. The bactericidal effect was found to be related to the molecular composition and organization in the top 2-3 nm of the surface, and increased with increasing hydrophilicity and pyridinium concentration of the surface.
Citation
Langmuir
Volume
22

Keywords

antibacterial polymers, bactericidal surfaces, fluorinated block polymers, NEXAFS, polymers, pyridinium, XPS

Citation

Krishnan, S. , Ward, R. , Hexemer, A. , Sohn, K. , Lee, K. , Angert, E. , Fischer, D. , Kramer, E. and Ober, C. (2006), Surfaces of Fluorinated Pyridinium Block-Copolymers with Enhanced Antibacterial Activity, Langmuir (Accessed March 5, 2024)
Created January 18, 2006, Updated October 12, 2021