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Surfaces of Fluorinated Pyridinium Block-Copolymers with Enhanced Antibacterial Activity



Sitaraman Krishnan, R J. Ward, A Hexemer, K E. Sohn, K L. Lee, E R. Angert, Daniel A. Fischer, E J. Kramer, Christopher K. Ober


Polystyrene-block-poly(4-vinylpyridine) copolymers were quaternized with 1-bromohexane and 6-perfluorooctyl-1-bromohexane. Surfaces prepared from these polymers were characterized by contact angle measurements, near-edge X-ray absorption fine structure (NEXAFS) spectroscopy and X-ray photoelectron spectroscopy (XPS). The fluorinated pyridinium surfaces showed enhanced antibacterial activity compared to their non-fluorinated counterparts. Even a polymer with a relatively low molecular weight pyridinium block showed high antimicrobial activity. The bactericidal effect was found to be related to the molecular composition and organization in the top 2-3 nm of the surface, and increased with increasing hydrophilicity and pyridinium concentration of the surface.


antibacterial polymers, bactericidal surfaces, fluorinated block polymers, NEXAFS, polymers, pyridinium, XPS


Krishnan, S. , Ward, R. , Hexemer, A. , Sohn, K. , Lee, K. , Angert, E. , Fischer, D. , Kramer, E. and Ober, C. (2006), Surfaces of Fluorinated Pyridinium Block-Copolymers with Enhanced Antibacterial Activity, Langmuir (Accessed March 5, 2024)
Created January 18, 2006, Updated October 12, 2021