Structured light in diffuse optical imaging

Published: September 16, 2018


Joseph P. Angelo, Sez-Jade Chen, Marien Ochoa, Ulas Sunar, Sylvain Gioux, Xavier Intes


Diffuse optical imaging probes deep living tissue enabling structural, functional, metabolic, and/or molecular imaging. Recently, thanks to the availability of spatial light modulators, wide-field quantitative diffuse optical techniques have been implemented that benefit greatly from structured light methodologies. Such implementations facilitate the quantification and characterization of depth-resolved optical and physiological properties of thick and deep tissue at fast acquisition speeds. In this review we summarize the current state of work and applications in the three main techniques leveraging structured light: spatial frequency domain imaging, optical tomography, and single pixel imaging. After a brief introduction, in Part 1 the theory, measurement and analysis of spatial frequency domain imaging is described. Then, advanced theories, processing and imaging systems are summarized. Last, preclinical and clinical applications on physiological measurements for guidance and diagnosis are summarized. In Part 2, general theory and method development of tomographic approaches as well as applications including fluorescence molecular tomography are introduced. Lastly, recent developments of single-pixel imaging methodologies and applications are reviewed in Part 3.
Citation: Journal of Biomedical Optics
Volume: 24
Issue: 7
Pub Type: Journals


optical imaging, structured illumination, diffusion theory, tomography
Created September 16, 2018, Updated November 10, 2018