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Structural Analysis of Soft Multicomponent Nanoparticle Clusters Using Electrospray Differential Mobility Analysis with Transmission Electron Microscopy

Published

Author(s)

Leonard F. Pease , Jeremy Feldblyum, Silvia H. DePaoli Lacaerda, Rajesekhar Anumolu, Peter Yim, Matthew L. Clarke, Hyeong G. Kang, Jeeseong C. Hwang

Abstract

Rapid and quantitative techniques are essential to analyze soft multicomponent nanoparticle clusters. Here we combine electrospray differential mobility analysis (ES-DMA), which measures the size of the entire cluster, with transmission electron microscopy (TEM), which detects the hard components, to determine the presence and composition of the softer components. Results demonstrate the power of the combined analysis to quantify the composition of soft coronas on nanoparticles and the number of quantum dots attached to lambda phage.
Citation
Nano Letters
Volume
4
Issue
11

Keywords

composite nanoparticles, electrospray differential mobility analysis, quantum dot, virus, phage, streptavidin.

Citation

Pease, L. , Feldblyum, J. , DePaoli Lacaerda, S. , Anumolu, R. , Yim, P. , Clarke, M. , Kang, H. and Hwang, J. (2010), Structural Analysis of Soft Multicomponent Nanoparticle Clusters Using Electrospray Differential Mobility Analysis with Transmission Electron Microscopy, Nano Letters (Accessed February 26, 2024)
Created October 21, 2010, Updated October 12, 2021