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Strong, Macroporous, and in Situ-Setting Calcium Phosphate Cement Layered Structures



Hockin D. Xu, Lisa E. Carey, Elena F. Burguera


Calcium phosphate cement (CPC) is highly promising for clinical uses due to its in situ-setting ability, excellent osteoconductivity and bone-replacement capability. However, the low strength limits its use to non-load-bearing applications. The objectives of this study were to develop a layered CPC structure by combining a macroporous CPC layer with a strong CPC layer, and to investigate the effects of porosity and layer thickness ratios. The rationale was for the macroporous layer to accept tissue ingrowth, while the fiber-reinforced strong layer would provide the needed early-strength. A biopolymer chitosan was incorporated to strengthen both layers. Flexural strength, S, (mean sd; n = 6) of CPC-scaffold decreased from (9.7 1.2) MPa to (1.8 0.3) MPa (p


bone repair, calcium phosphate cement, hydroxyapatite, layered structure, strength macroporosity


Xu, H. , Carey, L. and Burguera, E. (2007), Strong, Macroporous, and in Situ-Setting Calcium Phosphate Cement Layered Structures, Biomaterials, [online], (Accessed July 19, 2024)


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Created May 26, 2007, Updated February 19, 2017