Xu, H.
, Carey, L.
and Burguera, E.
(2007),
Strong, Macroporous, and in Situ-Setting Calcium Phosphate Cement Layered Structures, Biomaterials, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=852723
(Accessed June 7, 2023)
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Strong, Macroporous, and in Situ-Setting Calcium Phosphate Cement Layered Structures
Published
Author(s)
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Abstract
Calcium phosphate cement (CPC) is highly promising for clinical uses due to its in situ-setting ability, excellent osteoconductivity and bone-replacement capability. However, the low strength limits its use to non-load-bearing applications. The objectives of this study were to develop a layered CPC structure by combining a macroporous CPC layer with a strong CPC layer, and to investigate the effects of porosity and layer thickness ratios. The rationale was for the macroporous layer to accept tissue ingrowth, while the fiber-reinforced strong layer would provide the needed early-strength. A biopolymer chitosan was incorporated to strengthen both layers. Flexural strength, S, (mean sd; n = 6) of CPC-scaffold decreased from (9.7 1.2) MPa to (1.8 0.3) MPa (pCitation
Biomaterials
Volume
28
Pub Type
Journals
Download Paper
Keywords
bone repair, calcium phosphate cement, hydroxyapatite, layered structure, strength macroporosity
Citation
Created May 26, 2007, Updated February 19, 2017