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Strong, Macroporous, and in Situ-Setting Calcium Phosphate Cement Layered Structures

Published

Author(s)

Hockin D. Xu, Lisa E. Carey, Elena F. Burguera

Abstract

Calcium phosphate cement (CPC) is highly promising for clinical uses due to its in situ-setting ability, excellent osteoconductivity and bone-replacement capability. However, the low strength limits its use to non-load-bearing applications. The objectives of this study were to develop a layered CPC structure by combining a macroporous CPC layer with a strong CPC layer, and to investigate the effects of porosity and layer thickness ratios. The rationale was for the macroporous layer to accept tissue ingrowth, while the fiber-reinforced strong layer would provide the needed early-strength. A biopolymer chitosan was incorporated to strengthen both layers. Flexural strength, S, (mean sd; n = 6) of CPC-scaffold decreased from (9.7 1.2) MPa to (1.8 0.3) MPa (p
Citation
Biomaterials
Volume
28

Keywords

bone repair, calcium phosphate cement, hydroxyapatite, layered structure, strength macroporosity

Citation

Xu, H. , Carey, L. and Burguera, E. (2007), Strong, Macroporous, and in Situ-Setting Calcium Phosphate Cement Layered Structures, Biomaterials, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=852723 (Accessed July 19, 2024)

Issues

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Created May 26, 2007, Updated February 19, 2017