Spatial Distribution of Hydrophobic Drugs in Model Nanogel-core Star Polymers
Vivek M. Prabhu, Guangmin Wei, Robert D. Miller, Victoria A. Piunova, William Swope, Amber Carr
Star polymers with a cross-linked nanogel-core are promising carriers of cargo for therapeutic applications due the synthetic control of amphiphilicity of arms and the stability to infinite dilution. Three nanogel-core star polymers were investigated to understand how the arm block composition controls model drug loading efficiency and its spatial distribution. The spatial distribution profiles of hydrophobic core, hydrophilic corona and encapsulated drug were determined by small-angle neutron scattering (SANS). SANS provides the nm-scale sensitivity to determine how the block arm chemistry enhances the sequestering of ibuprofen, a model hydrophobic drug. Validated molecular dynamics simulations capture the trends in drug profile and polymer segment distribution. This work provides a basis to study structure-function relationship in macromolecular-based carriers of cargo towards validated and predictive simulation.
, Wei, G.
, Miller, R.
, Piunova, V.
, Swope, W.
and Carr, A.
Spatial Distribution of Hydrophobic Drugs in Model Nanogel-core Star Polymers, Journal of Physical Chemistry B, [online], https://doi.org/10.1021/acs.macromol.7b02061
(Accessed December 5, 2023)