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Solid-Phase Synthesis of Ammonium Ionenes



Matthew T. Hunley, Kathryn L. Beers


Ionenes are polyelectrolytes with the charge along the polymer backbone. These polymers possess a precisely-defined charge density, making them ideal as physical crosslinkers for high performance elastomers as well as gene transfection agents. However, molecular weight and polydisperty are difficult to control, and synthetic parameters such as stoichiometric imbalances and endcapping agents only offer limited control. In this work, we designed model surfaces for the solid-phase synthesis of ionenes from silicon. Model reactions identified the optimum reaction conditions of 50 °C for 45 min per monomer reaction. Preliminary X-ray photoelectron spectroscopy analysis indicated that brush growth does not proceed quantitatively, presumably due to steric and ionic effects in the growing brush layer. This solid-phase synthesis will enable us to prepare ionenes with precisely defined molecular weights, polydispersities, and monomer sequences.
Proceedings Title
2012 IUPAC World Polymer Congress
Conference Dates
June 25-29, 2012
Conference Location
Blacksburg, VA


Hunley, M. and Beers, K. (2012), Solid-Phase Synthesis of Ammonium Ionenes, 2012 IUPAC World Polymer Congress, Blacksburg, VA, [online], (Accessed April 13, 2024)
Created June 24, 2012, Updated February 19, 2017