In Situ Formation of Blends By Photopolymerization of Poly(ethylene glycol) Dimethacrylate and Polylactide
K J. Zhang, Carl Simon Jr., N Washburn, Joseph M. Antonucci, Sheng Lin-Gibson
Blends of crosslinked poly(ethylene glycol dimethacrylate) (PEGDMA) with poly (D, L-lactide) (PLA) were prepared by mixing photo-activated PEGDMA (molecular mass: 875 g/mol) and PLA, and subsequently photopolymerizing with visible light. The effects of PLA molecular mass and content on the rheological properties of the PEGDMA/PLA mixtures, and on degree of vinyl conversion (DC), was well as miscibility, microstructure, mechanical properties, in vitro swelling behavior and cellular response of the blends were studied. PLA-2K (molecular mass: 2096 g/mol) and PLA-63K (molecular mass: 63000 g/mol) formed miscible and partially miscible blends with poly(PEGDMA), respectively. The addition of the PLA-2K did not affect the immediate or post-cure (> 24 h) DC of the PEGDMA upon photo-polymerization. However, the PLA-63K decreased the immediate DC of the PEGDMA, which can be increased through extending the curing time or post-curing period.Compared to the crosslinked PEGDMA and PLA-2K/PEGDMA blends, PLA-63K/PEGDMA blends were significantly stronger, stiffer and tougher. Both types of blends and poly(PEGDMA) swelled when soaked in a phosphate buffered saline (PBS) solution. The attachment and spreading of MCT3-E1 cell increased with increasing PLA-63K content in the blends. The facile and rapid formation of PEGDMA/PLA blends by photopolymerization represents a novel and efficient approach to a unique class of biomaterials with wide spectra of properties.
, Simon Jr., C.
, Washburn, N.
, Antonucci, J.
and Lin-Gibson, S.
In Situ Formation of Blends By Photopolymerization of Poly(ethylene glycol) Dimethacrylate and Polylactide, Biomacromolecules, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=852833
(Accessed June 1, 2023)