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Single Molecule Mass Spectrometry in Solution Using a Solitary Nanopore

Published

Author(s)

Joseph W. Robertson, Claudio G. Rodrigues, Oleg V. Krasilnikov, Vincent M. Stanford, Kenneth A. Rubinson, John J. Kasianowicz

Abstract

A solitary protein nanometer-scale pore provides the basis for single molecule mass spectrometry in solution. Individual poly(ethylene glycol) molecules of different mass that enter a nanopore cause distinct and statistically resolved conductance states. The technique shows the potential for measuring detailed properties of individual molecules.
Proceedings Title
Proceedings of the National Academy of Sciences of the United States of America
Volume
104
Issue
20
Conference Dates
August 19, 2007-August 23, 2003
Conference Location
Boston, MA, USA
Conference Title
American Chemical Society, 234th National Meeting

Citation

Robertson, J. , Rodrigues, C. , Krasilnikov, O. , Stanford, V. , Rubinson, K. and Kasianowicz, J. (2007), Single Molecule Mass Spectrometry in Solution Using a Solitary Nanopore, Proceedings of the National Academy of Sciences of the United States of America, Boston, MA, USA, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=32506 (Accessed February 27, 2024)
Created May 14, 2007, Updated October 12, 2021