Short-Time Dynamics of Proteins in Solutions Studied by Neutron Spin Echo
Dynamics of proteins in solutions include translational, rotational, and internal motions that are linked to different properties of protein solutions. Because most proteins are small with the sizes just a few nanometers, the time scale for its short time dynamics usually range from a few nanoseconds to a few hundreds of nanoseconds. At the short-time limit, a protein usually does not rotate too much. The protein short-time dynamics have been shown to be useful to study protein cluster formation, gelation transitions of concentrated protein systems, and protein internal motions. Neutron spin echo, which is able to measure protein motions with the right correlation time at the appropriate length scale, is ideally suitable to study the short-time dynamics of proteins in solutions. Here we review recent activities of using neutron spin echo to study the protein short-time motions. Despite all the progresses, there are still both theoretical and experimental challenges to fully exploit the capability of neutron spin echo to study protein dynamics.
Short-Time Dynamics of Proteins in Solutions Studied by Neutron Spin Echo, Current Opinion in Colloid & Interface Science, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=927729
(Accessed February 23, 2024)