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Scalable additive construction of arrayed microstructures with encoded properties for bioimaging



Matthew DiSalvo, Belén Cortés Llanos, Cody LaBelle, David Murdoch, Nancy Allbritton


Microarrays are essential components of analytical instruments. The elements of microarrays may be imbued with additional functionalities and encodings using composite materials and structures, but traditional microfabrication methods present substantial barriers to fabrication, design, and scalability. In this work, a tool-free technique is reported to additively batch-construct micromolded, composite, and arrayed microstructures. The method required only a compatible carrier fluid to deposit a material onto a substrate with some topography. Permutations of this basic fabrication approach were leveraged to gain control over the volumes and positions of deposited materials within the microstructures. As a proof of concept, cell micro-carrier arrays were constructed to demonstrate a range of designs, compositions, functionalities, and applications for composite microstructures. This approach is envisioned to enable the fabrication of complex composite biological and/or synthetic microelements for biosensing, cellular analysis, and biochemical screening.


Microfabrication, Microarray Analysis, Single-Cell Analysis, Biologic Assays


DiSalvo, M. , Cortés Llanos, B. , LaBelle, C. , Murdoch, D. and Allbritton, N. (2022), Scalable additive construction of arrayed microstructures with encoded properties for bioimaging, Micromachines, [online], , (Accessed June 18, 2024)


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Created August 25, 2022, Updated November 29, 2022