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Salivary Fluoride From Fluoride Dentifrices or Rinses After Use of a Calcium Pre-Rinse or Calcium Dentifrice



Gerald L. Vogel, David Shim, Gary E. Schumacher, Clifton M. Carey, Laurence C. Chow, Shozo Takagi


Fluoride (F) in oral fluids, which appears to be primarily responsible for the cariostatic effect of this ion, appears to be maintained by the release of fluoride from bioavailable calcium - fluoride reservoirs such as calcium fluoride (CaF2) or bacterially bound calcium-fluoride. The low concentration of free calcium (Ca) in such reservoirs however, can limit the formation of these deposits. We have suggested that a concentrated Ca pre-rinse given immediately before fluoride therapy would increase the formation of such reservoirs. Recently, a preliminary study, with a small number of non-fasting subjects, demonstrated that a Ca rinse (150 mmol/L calcium lactate) given before a 12 mM (225 ppm) F (sodium fluoride, NaF) rinse produced a very large increase in the 1 h salivary F compared to the NaF rinse alone. In this study we repeated the previous Ca rinse/F rinse study with a larger group of fasting subjects, tested a delivery system in which Ca was applied as a fluoride free dentifrice (0.084 g calcium glycerolphosphate per g of dentifrice), and tested the 150 mM Ca pre-rinse with a conventional 1100 ppm NaF dentifrice (Crest). Finally a reverse application was tested in which the NaF rinse was administered before the Ca rinse. The results (12 subjects) indicated that all Ca pre-rinses significantly increased the 1 h saliva F relative to corresponding NaF treatments: (1) A Ca pre-rinse followed by a 60 s 225 ppm F rinse produced a 4.6x increase in the 1 h salivary F over a F rinse alone. (2) A 3.6x increase was produced when the Ca was given as a dentifrice. However, decreasing the F rinsing from 60 s to 10 s in this experiment only decreased the 1 h salivary F about 39%. (3) A 150 mmol/L Ca rinse given before a conventional 1100 ppm F dentifrice increased 1 h salivary F 2.3x over the F dentifrice alone. Finally, a F rinse given before a Ca rinse did not increase the 1 h salivary F. The study suggests that administration of a moderate to high concentration of Ca, as a rinse.
Caries Research


calcium, dentifrice, fluoride, rinse, saliva


Vogel, G. , Shim, D. , Schumacher, G. , Carey, C. , Chow, L. and Takagi, S. (2006), Salivary Fluoride From Fluoride Dentifrices or Rinses After Use of a Calcium Pre-Rinse or Calcium Dentifrice, Caries Research, [online], (Accessed July 16, 2024)


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Created May 1, 2006, Updated February 17, 2017