Rhodopsin is a retinal photoreceptor protein of bipartite structure consisting of the transmembrane protein opsin and the light Sensitive chromophore 11-cis-retinal, linked to opsin via a protonated Schiff base. Studies on rhodopsin have unveiled many structural and functional features that are common to a large and pharmacologically important group of proteins from the G-protein-coupled receptor (GPCR) superfamily, of which rhodopsin is the best-studied member. In this work, the main emphasis will be on structural investigations. In particular, the high-resolution structure of bovine rhodopsin provides a template for understanding how GPCRs work and highlights its central importance to the visual process.
Annual Review of Biophysics and Biomolecular Structure
crystal structure, G-protein-coupled receptors, phototransduction, rhodopsin, signal transduction, transmembrane protein, vision, vitamin A
Rhodopsin Chemistry and Structure, Annual Review of Biophysics and Biomolecular Structure
(Accessed February 23, 2024)