Rheopexy of Synovial Fluid and Protein Aggregation
Katherine Oates, Wendy Krause, Ronald L. Jones, R H. Colby
Bovine synovial fluid and albumin solutions of similar concentration are rheopectic (stress increases with time in steady shear). This unusual flow characteristic is caused by protein aggrega- tion, and the total stress is enhanced by entanglement of this tenuous protein network with the long-chain polysaccharide sodium hyaluronate under physiological conditions. Neutron scattering measurements on albumin solutions demonstrate protein aggregation and all measurements are consistent with a weak dipolar attraction energy (of order 3 kT) that is most likely augmented by hydrophobic interactions and/or disulfide bond formation between proteins. Protein aggregation appears to play an important role in the mechanical properties of blood and synovial fluid. We also suggest a connection between the observed rheopexy and the remarkable lubrication properties of synovial fluid.
, Krause, W.
, Jones, R.
and Colby, R.
Rheopexy of Synovial Fluid and Protein Aggregation, Journal Of The Royal Society Interface, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=852548
(Accessed December 9, 2023)