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A Review of the DNA Standard Reference Materials Developed by the National Institute of Standards and Technology

Published

Author(s)

Barbara C. Levin, He Cheng, Margaret C. Kline, Janette W. Redman, Kristy L. Richie

Abstract

The Standard Reference Materials Program at the U.S. National Institute of Standards and Technology (NIST) has three human DNA Standard Reference Materials (SRM 2390, SRM 2391a, and SRM 2392) currently available. Both the DNA Profiling SRM 2390 and the Polymerase Chain Reaction (PCR) - based DNA Profiling 2391a are intended for use in forensic and paternity identifications, for instructional law enforcement, or non-clinical research purposes and are not intended for clinical diagnostics. The mitochondrial DNA (mtDNA) SRM 2392 is to provide standardization and quality control when performing PCR and sequencing any segment or the entire 16,569 base pairs that comprise human mitochodrial DNA. SRM 2392 is designed for use by the forensic, medical and toxicological communities for human identification, disease diagnosis or mutation detection.
Citation
Fresenius Journal of Analytical Chemistry
Volume
370
Issue
2-3

Keywords

DNA, forensic, human, medical diagnostics, mitochondrial DNA, PCR, RFLP, short tandem repeats, standard reference material

Citation

Levin, B. , , H. , Kline, M. , Redman, J. and Richie, K. (2001), A Review of the DNA Standard Reference Materials Developed by the National Institute of Standards and Technology, Fresenius Journal of Analytical Chemistry (Accessed April 24, 2024)
Created June 1, 2001, Updated February 17, 2017