Remineralization Effects of A Two-Solution Fluoride Mouthrinse: An in situ Study

Published

October 1, 1999

Author(s)

Laurence C. Chow, Shozo Takagi, Clifton M. Carey, B A. Sieck

Abstract

Results from previous studies showed that a two-component fluoride (F) rinse is significantly more effective than a NaF rinse of the same F content 250 g/g (ppm) in remineralizing enamel and root lesions in an in vitro cyclic de- and remineralization model. In the present study the two-solution rinse and two NaF rinses with F contents of 250 ppm and 1000 ppm were evaluated in an intraoral remineralization model. Caries-like lesions were formed in the enamel of extracted human molars with the use of a pH 4 demineralizing solution. Thin sections of the(approximately}120 mm) containing lesions were prepared, and the mineral contents of the lesions were assessed by quantitative micro-radiography. With the cut surfaces protected by nail varnish, the sections in 3 groups were mounted with wax in the lingual areas of a removable mandibular appliance. Each of the seven subjects wore such an appliance for 14 days continuously except during subject's eating, drinking and carrying out oral hygiene procedures. Twice daily (after breakfast and before bedtime) the subjects received a 1 min rinse with 20 mL of (1) 250 ppm F NaF rinse, (2) 1000 ppm F NaF rinse, or (3) 228 ppm F two-component F rinse. At the end of the experimental period, the sections were retrieved, and the mineral contents of the lesions were again assessed quantitatively. The results show that both the 1000 ppm NaF and 228 ppm two-solution rinses were more effective (p < 0.05) than the 250 ppm F NaF rinse in reducing lesion parameters, i.e., in producing remineralization. However, the remineralization induced by the two-component rinse was statistically equivalent (p > 0.05) to that produced by the NaF rinse with 4 times the F content (1000 ppm). These results suggest that highly effective low F dose rinses or dentifrice's can be formulated.

Citation

Journal of Dental Research

Volume

79

Issue

4

Pub Type

Journals

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Keywords

calcium fluoride, enamel, fluoride, fluoride rinse, in situ model, remineralization, sodium hexafluorosilicate, Dentistry

Citation

Chow, L. , Takagi, S. , Carey, C. and Sieck, B. (1999), Remineralization Effects of A Two-Solution Fluoride Mouthrinse: An in situ Study, Journal of Dental Research, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=851496 (Accessed May 10, 2025)