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Reduced Hardening Time of Calcium Phosphate Cements



Milenko Markovic, S. Takagi, Laurence C. Chow


The first self-hardening calcium phosphate cement (CPC) consisting of tetracalcium phosphate (TTCP, Ca4(PO4)2O) and dicalcium phosphate anhydrous (DCPA, CaHPO4) or dicalcium phosphate dihydrate (DCPD, CaHPO4 H x 2H2O) was developed in 1987. The CPC composed of TTCP and DCPA was approved in 1996 by the Food and Drug Administration for cranial defects repair applications in humans, thus becoming the first CPC available for clinical use in the United States. This cement hardens in less than or equal to} 30 min with water and in about 5 min with a 0.25 mol/L phosphate solution, forming calcium hydroxyapatite (HA). For some clinical applications control of cement hardening time (HT) can be a very important factor and several powdered additives were used to change HT of CPC. In this study the reduction of CPC HT with the use of (a) lower concentrations of phosphate solutions or (b) different amounts of low-crystalline HA (lc-HA) as an additive was investigated. Additionally, the effect of lc-HA on HT for cement composed of tricalcium phosphate (α-TCP, α-Ca3(PO4)2) and calcium carbonate (CaCO3) was studied.
Proceedings Title
Proceedings of the 6th World Biomaterials Congress
Conference Dates
May 15-20, 2000
Conference Location
Conference Title
Biomaterials Forum


calcium, calcium phosphate cement, crystallinity, hardening time, hydroxyapatite, phosphate


Markovic, M. , Takagi, S. and Chow, L. (2008), Reduced Hardening Time of Calcium Phosphate Cements, Proceedings of the 6th World Biomaterials Congress, Undefined (Accessed April 16, 2024)
Created October 16, 2008