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Reaction Kinetics and Gel Properties of Blocked Disocyinate Cross-Linked Chitosan Hydrogels



Sheng Lin-Gibson, H J. Walls, S B. Kennedy, E R. Welsh


Cure kinetics and network properties of hydrogels prepared by the reaction of chitosan and a water-soluble blocked diisocyanate crosslinker have been measured using swelling experiments and rheometry. The gel time measured by two different rheological methods, the rate equivalence of the change in modulus as a function of reaction time (G'G crossover) and the critical gel via the Winter-Chambon approach, are comparable. The reaction rate increased with increased temperature following the Arrhenius behavior, from which apparent activation energies can be determined. The network moduli can be tailored by adjusting the ratio of chitosan to crosslinker or the solution concentration. This allows for the formation of processable chemically crosslinked chitosan hydrogels with controlled kinetics and mechanical properties.
Carbohydrate Polymers


chitosan, crosslink kinetics, gel modulus, hydrogels


Lin-Gibson, S. , Walls, H. , Kennedy, S. and Welsh, E. (2003), Reaction Kinetics and Gel Properties of Blocked Disocyinate Cross-Linked Chitosan Hydrogels, Carbohydrate Polymers, [online], (Accessed July 23, 2024)


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Created May 19, 2003, Updated February 19, 2017