Reaction Kinetics and Gel Properties of Blocked Disocyinate Cross-Linked Chitosan Hydrogels

Published

May 19, 2003

Author(s)

Sheng Lin-Gibson, H J. Walls, S B. Kennedy, E R. Welsh

Abstract

Cure kinetics and network properties of hydrogels prepared by the reaction of chitosan and a water-soluble blocked diisocyanate crosslinker have been measured using swelling experiments and rheometry. The gel time measured by two different rheological methods, the rate equivalence of the change in modulus as a function of reaction time (G'G crossover) and the critical gel via the Winter-Chambon approach, are comparable. The reaction rate increased with increased temperature following the Arrhenius behavior, from which apparent activation energies can be determined. The network moduli can be tailored by adjusting the ratio of chitosan to crosslinker or the solution concentration. This allows for the formation of processable chemically crosslinked chitosan hydrogels with controlled kinetics and mechanical properties.

Citation

Carbohydrate Polymers

Pub Type

Journals

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Keywords

chitosan, crosslink kinetics, gel modulus, hydrogels

Citation

Lin-Gibson, S. , Walls, H. , Kennedy, S. and Welsh, E. (2003), Reaction Kinetics and Gel Properties of Blocked Disocyinate Cross-Linked Chitosan Hydrogels, Carbohydrate Polymers, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=852173 (Accessed November 5, 2025)