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Reaction of Calcium Phosphate Cements Consisting of Different Amounts of Tetracalcium Phosphate and Dicalcium Phosphate Anhydrous



K Ishikawa, Shozo Takagi, Laurence Chow, K Suzuki


Calcium phosphate cements (CPC) consisting of different amounts of tetracalcium phosphate (TTCP) and dicalcium phosphate anhydrous (DCPA) (TTCP/DCPA molar ratio from 0.25 to 2.00) were prepared for the further understanding of the reaction and factors which could influence the properties of CPCs. Quantitative x-ray diffraction patterns, fourier-transformation infrared spectra and diametral tensile strength of the set mass were measured along with pH measurement of the CPC suspension. Calcium-deficient hydroxyapatite (d-HAP) with a calcium to phosphate molar ratio of approximately 1.5 was formed initially from the CPC consisting of an equimolar mixture of TTCP and DCPA. This gradually transformed into stoichiometric HAP (s-HAP) with increasing incubation time. s-HAP was formed from the initial stage when the CPC contained an excess amount of TTCP. In contrast, maturation to s-HAP was slow when the CPC contained larger amounts of DCPA. The highest mechanical strength of set CPC was found when the CPC consisted of an equimolar mixture of TTCP and DCPA, and the mechanical strength decreased as the TTCP/DCPA molar ratio diverged from 1.00. We concluded, therefore, that the setting reaction and the nature of the resulting set mass are dependent on many factors including the different molar ratio of TTCP and DCPA.
Journal of Biomedical Materials Research


biomaterial, calcium phosphate, dicalcium phosphate dihydrate, hydroxyapatite, hydroxyapatite cement, self-setting cement, tetracalcium phosphate


Ishikawa, K. , Takagi, S. , Chow, L. and Suzuki, K. (1999), Reaction of Calcium Phosphate Cements Consisting of Different Amounts of Tetracalcium Phosphate and Dicalcium Phosphate Anhydrous, Journal of Biomedical Materials Research, [online], (Accessed May 19, 2024)


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Created September 14, 1999, Updated October 12, 2021