Quantitative Measurement of the Polydispersity in the Extent of Functionalization of Glass Forming Resorcinarenes

Published

May 1, 2009

Author(s)

William E. Wallace, Kathleen M. Flynn, Charles M. Guttman, David L. VanderHart, Vivek M. Prabhu, Anuja De Silva, Nelson Felix, Christopher K. Ober

Abstract

The polydispersity in the degree of functionalization for two calix[4]resorcinarenes was determined by measuring their molecular mass distribution with matrix-assisted laser desorption/ionization time of flight mass spectrometry. A mathematical method for polydisperse materials is described that creates a calibration curve to correct the ion intensities in the mass spectrum to give a more reliable molecular mass distribution. Correction is required due to various sample preparation and instrumental effects that may produce a systematic bias on the number of oligomers measured. This method employs gravimetric mixtures of analytes with different degrees of functionalization. One calix[4]resorcinarene was found to give accurate molecular mass distributions with little correction, while another having a very similar molecular structure was found to exhibit strong over counting of oligomers with a high degree of functionalization.

Citation

Rapid Communications in Mass Spectrometry

Volume

23

Pub Type

Journals

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Keywords

glass, mass spectrometry, photolithography

Citation

Wallace, W. , Flynn, K. , Guttman, C. , VanderHart, D. , Prabhu, V. , De, A. , Felix, N. and Ober, C. (2009), Quantitative Measurement of the Polydispersity in the Extent of Functionalization of Glass Forming Resorcinarenes, Rapid Communications in Mass Spectrometry, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=854457 (Accessed October 18, 2025)