Quantifying Cell-Response to Materials Through Population Analyses Enabled by High-Throughput Techniques

Published

April 1, 2003

Author(s)

S B. Kennedy, Ying Mei, R Gross, N Washburn, Eric J. Amis

Abstract

Efforts in combinatorial materials science at NIST have evolved into three interwoven toolsets for exploring cell response to materials: material library preparation, high-throughput screening, and statistical treatment of population distributions. As the material library available for investigating cell-biomaterial interactions continues to expand, image acquisition and analysis have been exposed as bottlenecks in the high-throughput approach. Furthermore, sampling biases inherent to imaging techniques are amplified as gradient samples are used to facilitate the exploration of a large parameter space. High throughput image acquisition and analysis techniques are now being refined and applied to several material systems. We will report results from these investigations, including a rigorous statistical analysis comparing several parametric and nonparametric tests.

Proceedings Title

Society for Biomaterials, Annual Meeting | 29th | |

Conference Dates

April 1, 2003

Conference Title

Transactions of the Society for Biomaterials

Pub Type

Conferences

Keywords

automated microscopy, biomaterials, cell culture parametric, nonparametric, statistical analysis

Citation

Kennedy, S. , Mei, Y. , Gross, R. , Washburn, N. and Amis, E. (2003), Quantifying Cell-Response to Materials Through Population Analyses Enabled by High-Throughput Techniques, Society for Biomaterials, Annual Meeting | 29th | | (Accessed December 11, 2024)