Skip to main content
U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Preparation of Nanoparticles by Continuous-Flow Microfluidics



Andreas Jahn, Joseph E. Reiner, Wyatt N. Vreeland, Don DeVoe, Laurie E. Locascio, Michael Gaitan


We review a variety of micro- and nanoparticle formulations produced with microfluidic methods. A diverse variety of approaches to generate micro-scale and nano-scale particles have been reported. Here we emphasize the use of microfluidics, specifically microfluidic systems that operate in a continuous flow mode, thereby allowing continuous generation of desired particle formulations. The generation of semiconductor quantum dots, metal colloids, emulsions, and liposomes is considered here. To emphasize the potential benefits of the continuous-flow microfluidic methodology for nanoparticle generation, preliminary data on the size distribution of liposomes formed using the microfluidic approach is compared to the traditional bulk alcohol injection method.
Journal of Nanoparticle Research


continuous flow microfluidics, emulsions, liposomes, metal colloids, nanoparticles, particle formation


Jahn, A. , Reiner, J. , Vreeland, W. , DeVoe, D. , Locascio, L. and Gaitan, M. (2008), Preparation of Nanoparticles by Continuous-Flow Microfluidics, Journal of Nanoparticle Research, [online], (Accessed April 20, 2024)
Created February 14, 2008, Updated October 12, 2021