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Premixed Rapid-Setting Calcium Phosphate Composites for Bone Repair



Lisa E. Carey, Hockin D. Xu, Carl G. Simon Jr., Shozo Takagi, Laurence C. Chow


Abstract (A-2000 character or less factual summary of most significant information. If document includes a significant bibliography or literature survey, cite it here. Spell out acronyms on first reference.) Although calcium phosphate cement (CPC) is promising for bone repair, its clinical use requires on site powder-liquid mixing and placement before the paste hardens. To shorten surgical time and improve graft properties, it is desirable to develop premixed CPC in which the paste remains stable during storage and hardens only after placement into the defect. The objective of this study was to develop premixed CPC that is capable of rapid setting when immersed in a physiological solution, and to investigate the physical properties and cell viability. Premixed CPCs were formulated via the following approach: Premixed CPC = CPC powder + nonaqueous liquid + gelling agent + hardening accelerator. Three premixed CPCs were thus developed: CPC-monocalcium phosphate monohydrate (MCPM), CPC-chitosan, and CPC-tartaric. Setting time for these new premixed CPCs ranged from 5.3 min to 7.9 min, significantly faster than 61.7 min for a premixed control CPC reported previously (p


bone repair, cell culture, cytotoxicity, hydroxyapatite, premixed calcium phosphate cement, rapid setting, strength


Carey, L. , Xu, H. , Simon, C. , Takagi, S. and Chow, L. (2005), Premixed Rapid-Setting Calcium Phosphate Composites for Bone Repair, Biomaterials, [online], (Accessed July 16, 2024)


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Created January 1, 2005, Updated February 19, 2017